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Featured Application
Automated quantitation of events with protein localized to the T:APC synapse using the ImageStream® system
Measurement of nuclear translocation in primary T cells using correlation analysis of images obtained on the ImageStream® system
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Kinetics of CpG internalization and sub-cellular organelle
co-localization within circulating human plasmcytoid dendritic cells
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Automated quantitation of events with protein localized to the T:APC synapse using the ImageStream® system
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Accurate and Reliable Multi-parametric Analysis of Apoptosis
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Simultaneous Measurement of NF-kB Translocation and Apoptosis
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Quantitation of Nuclear Translocation Events Using ImageStream Multispectral Imaging Cytometry
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Analysis of Apoptosis by Nuclear Fragmentation
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Quantitative Analysis of Pseudopod Formation
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Distinguishing Modes of Cell Death Using ImageStream Multispectral Imaging Cytometry
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Multiplexed Analysis of Cells and Beads with the ImageStream Imaging Flow Cytometer
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Analysis of Intracellular Molecular Trafficking Using ImageStream Multispectral Imaging
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GFP Expression and Subcellular Compartmentalization in Trypanosomes
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Posters
Automated Classification Of Apoptosis And Artifact Rejection Of Tunel Positive Cells
Presented at ISAC XXIII, May 2006
Image Data Exploration And Analysis Software
Presented at ISAC XXIII, May 2006
Assessment Of Protein Co-Localization With An Imaging Flow Cytometer And Novel Analytical Method
Presented at ISAC XXIII, May 2006
StreamLine eNewsletters
2007 Newsletters
2006 Newsletters
- StreamLine Volume 3 No. 4
- StreamLine Volume 3 No. 3
- StreamLine Volume 3 No. 2
- StreamLine Volume 3 No. 1
Press Releases
Amnis and Gene Company, Ltd Announce Agreement to Market ImageStream® Technology in China.
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Amnis Announces Release of Extended Depth of Field Option for the Imagestream system® System
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Amnis Announces Release of Multiple Upgrades to the Imagestream® System
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Amnis Announces Release of Turbo Upgrade to the Imagestream® System
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Featured Publication
Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
Blood (2007)
Additional Publications
Biphasic Regulation of Il2 Transcription in CD4 T Cells: Roles for TNF-α Receptor Signaling and Chromatin Structure.
Journal of Immunology (2008)
Link to Publication
IL-17A Inhibits the Expansion of IL-17A-Producing T Cells in Mice through “Short-Loop” Inhibition via IL-17 Receptor.
Journal of Immunology (2008)
Link to Publication
Multispectral imaging of hematopoietic cells: Where flow meets morphology
J. Immunol. Methods (2008)
Link to Publication
Quantitative image based apoptotic index measurement using
multispectral imaging flow cytometry: a comparison
with standard photometric methods.
Apoptosis (2008)
Link to Publication
IL-13 induces the expression of the alternative activation marker Ym1 in a subset of testicular macrophages.
J. Reprod. Immunol. (2008)
Link to Publication
Hunt for pluripotent stem cell -- Regenerative medicine search for almighty cell.
Journal of Autoimmunity 30 (2008)
Link to Publication
Microscopic imaging techniques for drug discovery.
Andrew Bullen
Nat Rev Drug Discov. (2008)
Link to Publication
The oncoprotein H-RasV12 increases mitochondrial metabolism.
Cancer Molecular Cancer (2007)
Link to Publication
Oncogenic CARD11 Mutations in Human Diffuse Large B Cell
Lymphoma.
SCIENCE (2008)
Link to Publication
Cyclooxygenase-2 independent effects of cyclooxygenase-2
inhibitors on oxidative stress and intracellular glutathione
content in normal and malignant human B-cells.
Cancer Immunol Immunother (2008)
Link to Publication
The ImageStream System: a key step to a new era in imaging.
Folia Histochem Cytobiol. (2007)
Link to Publication
Entamoeba histolytica Phagocytosis of Human Erythrocytes Involves PATMK, a Member of the Transmembrane Kinase Family.
PLOS (2008)
Link to publication
Image-Based Study of Interferongenic Interactions between Plasmacytoid Dendritic Cells and HSV-Infected Monocyte-Derived Dendritic Cells.
Immunological Investigations (2007)
Link to publication
Autophosphorylation docking site Tyr867 in Mertk allows for dissociation of multiple
signaling pathways for phagocytosis of apoptotic cells and down-modulation of LPSinducible
NF-κB transcriptional activation.
Journal of Biological Chemistry (2007)
Link to publication
Morphological characterization of very small embryonic- like stem cells (VSELs) by
image stream system analysis.
Journal of Cellular and Molecular Medicine (2007)
Link to publication
Phosphorylation by CK2 regulates Nap1 localization and function.
Molecular and Cellular Biology (2007)
Link to publication
Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus.
Blood(2007)
Link to publication
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module.
Nature(2007)
Link to publication
A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: Comparisons to a 4 h 51Cr-release assay.
J. Immunol. Meth. (2007)
Link to publication
Wnt signaling promotes hemato-endothelial cell development from human embryonic stem cells.
Blood (2007)
Link to publication
Tumorigenic Epithelial Stem Cells and Their Normal Counterparts.
Ernst Schering Foundation Symposium Proceedings (2007) Vol. 5, pp. 245–263.
IFN-αIs Not Sufficient to Drive Th1 Development Due to Lackof Stable T-bet Expression.
The Journal of Immunology (2007)
Link to publication
Rapid and Selective Death of Leukemia Stem and Progenitor cells Induced by the Compound
4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8).
Blood (2007)
Link to publication
The Unexpected Effect of Cyclosporin A on CD56+CD16 and CD56+CD16+ Natural Killer Cell Subpopulations.
Blood (2007)
Link to publication
Cellular Image Analysis and Imaging by Flow Cytometry.
Clinics in Laboratory Medicine (2007)
Link to publication
The Flow of Cytometry into Systems Biology.
Briefings in Functional Genomics and Proteomics(2007)
Link to publication
The Doublecortin-expressing Population in the Developing and Adult Brain Contains Multipotential Precursors in Addition to
Neuronal-lineage Cells.
The Journal of Neuroscience (2007)
Link to publication
NKT Cell Activation Mediates Neutrophil IFN-g Production and Renal Ischemia-Reperfusion Injury.
The Journal of Immunology (2007)
Link to publication
Aryl Hydrocarbon Receptor Activation during Influenza Virus Infection Unveils a Novel Pathway of IFN-gamma Production by
Phagocytic Cells.
The Journal of Immunology (2007).
Link to publication
Regulation of NF-κB Activation in T Cells via Association with the Adaptor Proteins ADAP and CARMA1
Science (2007) 316: 754-8
Link to publication
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
Science (2007)
Link to publication
Extended depth of field imaging for high speed cell analysis
Cytometry Part A (2007)
Link to publication
Quantitative analysis of protein co-localization on B cells opsonized with rituximab and complement using the ImageStream multispectral imaging cytometer
Journal of Immunological Methods. (2006)
Link to publication
IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-γ-deficient mice in a Th2-biased response.
Cellular Immunology (2006)
Link to publication
Receptor Cross-Linking on Human Plasmacytoid Dendritic Cells Leads to the Regulation of IFN-α Production
The Journal of Immunology (2006)
Link to publication
Asynchronous Progression through the Lytic Cascade and Variations in Intracellular Viral Loads Revealed by High-throughput Single-Cell Analysis of Kaposi's Sarcoma-Associated Herpesvirus Infection
Journal of Virology (2006)
Link to publication
Sensitivity measurement and compensation in spectral imaging
Cytometry Part A (2006)
Link to publication
KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice
Journal of Clinical Investigation
(2006)
Link to publication
Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression
The Journal of Immunology (2006)
Link to publication
Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow.
Journal of Immunological Methods (2006) 311:117-29.
Link to publication
Multispectral Imaging in Flow: A Technique for Advanced Cellular Studies in Flow Cytometry for Biotechnology
Link to publication
Cutting Edge: FADD Is Not Required for Antigen Receptor-Mediated NF-κB Activation
The Journal of Immunology (2005)
Link to publication
Upcoming Events
September 19-21, 2008
GLIIFCA
Milwaukee, WI
October 10-14, 2008
Clinical Cytometry Society
Portland, OR
October 19-22, 2008
New York Immunology Conference
Bolton Landing, NY
November 21-24, 2008
Autumn Immunology Conference
Chicago, IL
December 6-9, 2008
American Society of Hematology
San Francisco, CA
December 13-17, 2008
American Society for Cell Biology
San Francisco, CA
The visual power of microscopy and the statistical rigor of flow
cytometry are now combined in a single platform.
What can Multispectral Imaging Flow Cytometry on the ImageStream do
for you? The powerful combination of quantitative image analysis and
flow cytometry in a single platform creates exceptional new experimental
capabilities. Measure the amount, location and movement of molecules
on, in, or between cells. Measure the location and co-localization of
multiple markers on or in cells. Quantitate morphologically distinct
cell subpopulations. Dramatically expand the depth and range of questions
you can ask in a flow environment.
When you analyze your cells on the ImageStream you will see more – and know more – than you ever thought possible.
Find out more about ImageStream technology
View ImageStream eBrochure
EDFTM Extended Depth of Field Technology
A powerful new option for the ImageStream system
EDF technology uses a combination of specialized optics and unique image processing algorithms to project all structures within the cell into one crisp plane of focus. The extended depth of field offers substantial performance improvements and enables many new applications of the ImageStream system.
- Improve precision
- Simplify analysis
- Reduce acquisition time
- Enhance discrimination
- Increase resolution
- Enable new applications
Learn more about EDF technology and its applications
IDEAS® 3.0: newly upgraded image analysis software with exceptional power and flexibility
Just because an image analysis package is powerful doesn’t mean it should be hard to use.
IDEAS cell image analysis software gets you to your data quickly and easily
and gives you a rich suite of tools to analyze almost any problem. The
continually expanding IDEAS feature set offers over 250 features, many
developed just for the ImageStream system. 
- Every dot in a scatter plot is linked to a cell image – click on the dot and you will see the corresponding cell
- Virtual Cell Sorting – use familiar gating tools to define and inspect cell populations
- Image data and statistical data are fully integrated – complete statistics are always available for every population
- Powerful built-in algorithms calculate similarities between different images of the same cell -- colocalize signals without FRET!
One Instrument, Unlimited Applications
Many new applications are enabled by the ImageStream system, and many existing flow cytometry applications are dramatically improved. The following are just a few of the many ways in which the ImageStream can bring more power and insight to your research.
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| Cell Classification | Nuclear Translocation | Apoptosis | Surface Marker Colocalization |
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| Cell Conjugates | Pseudopod Formation | Phagocytosis | Molecular Trafficking |
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| FISH in Suspension | Gene Expression | Immune Synapse | Toxoplasma Gondii |
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For a complete listing of technical reports, application notes and publications, please visit our Applications page.
Expand the power of your ImageStream system with the addition of up to two more lasers
Multiple Lasers
Use a wider range of dyes and enable even more applications by adding
up to two additional lasers to the basic system. In addition to the
standard 488nm laser, you can now add a 375nm, a 405nm or a 658nm. The
lasers may be ordered installed on your ImageStream as field upgrades.
Click to receive more information about the Multilaser upgrade
